Dual action of neurokinin-1 antagonists on Mas-related GPCRs

The challenge of translating findings from animal models to the clinic is well known. An example of this challenge is the striking effectiveness of neurokinin-1 receptor (NK-1R) antagonists in mouse models of inflammation coupled with their equally striking failure in clinical investigations in huma...

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Foilsithe in:JCI Insight
Main Authors: Azimi, Ehsan, Reddy, Vemuri B., Shade, Kai-Ting C., Anthony, Robert M., Talbot, Sebastien, Pereira, Paula Juliana Seadi, Lerner, Ethan A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053144/
https://ncbi.nlm.nih.gov/pubmed/27734033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89362
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