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Substance P activates Mas-related G protein–coupled receptors to induce itch

BACKGROUND: Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1. OBJECTIVE...

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Podrobná bibliografie
Vydáno v:J Allergy Clin Immunol
Hlavní autoři: Azimi, Ehsan, Reddy, Vemuri B., Pereira, Paula Juliana Seadi, Talbot, Sebastien, Woolf, Clifford J., Lerner, Ethan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546940/
https://ncbi.nlm.nih.gov/pubmed/28219706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.12.980
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