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Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1
Mutant superoxide dismutase 1 (SOD1) selectively associates with spinal cord mitochondria in rodent models of SOD1-mediated amyotrophic lateral sclerosis. A portion of mutant SOD1 exists in a non-native/misfolded conformation that is selectively recognized by conformational antibodies. Misfolded SOD...
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| Veröffentlicht in: | Hum Mol Genet |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5052069/ https://ncbi.nlm.nih.gov/pubmed/23736301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt249 |
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