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Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice
Renal fibrosis is the hallmark of chronic kidney diseases (CKD) and its development and progression are significantly affected by epigenetic modifications. Rhein, a plant-derived anthraquinone, displays strong anti-fibrosis properties, but its protective mode of action remains incompletely understoo...
Guardat en:
| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5050540/ https://ncbi.nlm.nih.gov/pubmed/27703201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34597 |
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