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Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating

The flow of ions through membrane channels is precisely regulated by gates. The architecture and function of these elements have been studied extensively, shedding light on the mechanisms underlying gating. Recent investigations have focused on ion occupancy of the channel’s selectivity filter and i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mukherjee, Saptarshi, Thomas, N. Lowri, Williams, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050499/
https://ncbi.nlm.nih.gov/pubmed/27703263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34452
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