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A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment
Cardiac muscle contraction, triggered by the action potential, is mediated by the release of Ca(2+) from the sarcoplasmic reticulum through ryanodine receptor (RyR)2 channels. In situ, RyR2 gating is modulated by numerous physiological and pharmacological agents, and altered RyR2 function underlies...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Rockefeller University Press
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3409104/ https://ncbi.nlm.nih.gov/pubmed/22802361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110706 |
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