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A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment

Cardiac muscle contraction, triggered by the action potential, is mediated by the release of Ca(2+) from the sarcoplasmic reticulum through ryanodine receptor (RyR)2 channels. In situ, RyR2 gating is modulated by numerous physiological and pharmacological agents, and altered RyR2 function underlies...

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Detalhes bibliográficos
Main Authors: Mukherjee, Saptarshi, Thomas, N. Lowri, Williams, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409104/
https://ncbi.nlm.nih.gov/pubmed/22802361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110706
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