LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

Chronic Pseudomonas aeruginosa infections cause significant morbidity in patients with cystic fibrosis (CF). Over years to decades, P. aeruginosa adapts genetically as it establishes chronic lung infections. Nonsynonymous mutations in lasR, the quorum-sensing (QS) master regulator, are common in CF....

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:mBio
Prif Awduron: Feltner, John B., Wolter, Daniel J., Pope, Christopher E., Groleau, Marie-Christine, Smalley, Nicole E., Greenberg, E. Peter, Mayer-Hamblett, Nicole, Burns, Jane, Déziel, Eric, Hoffman, Lucas R., Dandekar, Ajai A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050340/
https://ncbi.nlm.nih.gov/pubmed/27703072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01513-16
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