LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

Chronic Pseudomonas aeruginosa infections cause significant morbidity in patients with cystic fibrosis (CF). Over years to decades, P. aeruginosa adapts genetically as it establishes chronic lung infections. Nonsynonymous mutations in lasR, the quorum-sensing (QS) master regulator, are common in CF....

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Detalhes bibliográficos
Publicado no:mBio
Principais autores: Feltner, John B., Wolter, Daniel J., Pope, Christopher E., Groleau, Marie-Christine, Smalley, Nicole E., Greenberg, E. Peter, Mayer-Hamblett, Nicole, Burns, Jane, Déziel, Eric, Hoffman, Lucas R., Dandekar, Ajai A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050340/
https://ncbi.nlm.nih.gov/pubmed/27703072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01513-16
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