Genetic and Transcriptomic Characteristics of RhlR-Dependent Quorum Sensing in Cystic Fibrosis Isolates of Pseudomonas aeruginosa

ABSTRACT In people with the genetic disease cystic fibrosis (CF), bacterial infections involving the opportunistic pathogen Pseudomonas aeruginosa are a significant cause of morbidity and mortality. P. aeruginosa uses a cell-cell signaling mechanism called quorum sensing (QS) to regulate many virule...

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Bibliographic Details
Main Authors: Kyle L. Asfahl, Nicole E. Smalley, Alexandria P. Chang, Ajai A. Dandekar
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2022-04-01
Series:mSystems
Subjects:
adaptation
cystic fibrosis
gene regulation
quorum sensing
transcriptomics
Online Access:https://journals.asm.org/doi/10.1128/msystems.00113-22
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