Novel Association of Genetic Markers Affecting CYP2A6 activity and Lung Cancer Risk

Metabolism of nicotine by cytochrome CYP2A6 is a suspected determinant of smoking dose and, consequently, lung cancer risk. We conducted a genome-wide association study (GWAS) of CYP2A6 activity, as measured by the urinary ratio of trans-3′-hydroxycotinine and its glucuronide conjugate over cotinine...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Patel, Yesha M., Park, Sunghim L., Han, Younghun, Wilkens, Lynne R., Bickeböller, Heike, Rosenberger, Albert, Caporaso, Neil, Landi, Maria Teresa, Brüske, Irene, Risch, Angela, Wei, Yongyue, Christiani, David C., Brennan, Paul, Houlston, Richard, McKay, James, McLaughlin, John, Hung, Rayjean, Murphy, Sharon, Stram, Daniel O., Amos, Christopher, Le Marchand, Loïc
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050097/
https://ncbi.nlm.nih.gov/pubmed/27488534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0446
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