Novel Association of Genetic Markers Affecting CYP2A6 activity and Lung Cancer Risk

Metabolism of nicotine by cytochrome CYP2A6 is a suspected determinant of smoking dose and, consequently, lung cancer risk. We conducted a genome-wide association study (GWAS) of CYP2A6 activity, as measured by the urinary ratio of trans-3′-hydroxycotinine and its glucuronide conjugate over cotinine...

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發表在:Cancer Res
Main Authors: Patel, Yesha M., Park, Sunghim L., Han, Younghun, Wilkens, Lynne R., Bickeböller, Heike, Rosenberger, Albert, Caporaso, Neil, Landi, Maria Teresa, Brüske, Irene, Risch, Angela, Wei, Yongyue, Christiani, David C., Brennan, Paul, Houlston, Richard, McKay, James, McLaughlin, John, Hung, Rayjean, Murphy, Sharon, Stram, Daniel O., Amos, Christopher, Le Marchand, Loïc
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050097/
https://ncbi.nlm.nih.gov/pubmed/27488534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0446
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