Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis

T cell Ig mucin-3 (Tim-3), an immune checkpoint inhibitor, shows therapeutic potential. However, the molecular mechanism by which Tim-3 regulates immune responses remains to be determined. In particular, very little is known about how Tim-3 works in innate immune cells. Here, we demonstrated that Ti...

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Vydáno v:Oncoimmunology
Hlavní autoři: Jiang, Xingwei, Zhou, Tingting, Xiao, Yan, Yu, Jiahui, Dou, Shuaijie, Chen, Guojiang, Wang, Renxi, Xiao, He, Hou, Chunmei, Wang, Wei, Shi, Qingzhu, Feng, Jiannan, Ma, Yuanfang, Shen, Beifen, Li, Yan, Han, Gencheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048770/
https://ncbi.nlm.nih.gov/pubmed/27757304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1211219
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