Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

Nuclear factor 90 (NF90) is a novel virus sensor that serves to initiate antiviral innate immunity by triggering stress granule (SG) formation. However, the regulation of the NF90-SG pathway remains largely unclear. We found that Tim-3, an immune checkpoint inhibitor, promotes the ubiquitination and...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Dou, Shuaijie, Li, Guoxian, Li, Ge, Hou, Chunmei, Zheng, Yang, Tang, Lili, Gao, Yang, Mo, Rongliang, Li, Yuxiang, Wang, Renxi, Shen, Beifen, Zhang, Jun, Han, Gencheng
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225388/
https://ncbi.nlm.nih.gov/pubmed/34110282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66501
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