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Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family

The human pocket proteins Rb, p107 and p130 are critical negative regulators of the cell cycle and contribute to tumor suppression. While strong structural conservation within the pocket protein family provides for some functional redundancy, important differences have been observed and may underlie...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Liban, Tyler J., Thwaites, Michael J., Dick, Frederick A., Rubin, Seth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048593/
https://ncbi.nlm.nih.gov/pubmed/27567532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.08.017
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