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Crystal Structure of the Unliganded Retinoblastoma Protein Pocket Domain

The retinoblastoma protein (Rb) regulates cell proliferation through its association with E2F transcription factors and other proteins. The Rb “pocket” domain primarily facilitates protein-protein interactions, and several structures of the pocket bound to E2F and tumorigenic viral proteins have bee...

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Hlavní autoři: Balog, Eva Rose M., Burke, Jason R., Hura, Greg L., Rubin, Seth M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092862/
https://ncbi.nlm.nih.gov/pubmed/21491492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23007
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