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Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control

Cyclin-dependent kinase (Cdk) phosphorylation of the Retinoblastoma protein (Rb) drives cell proliferation through inhibition of Rb complexes with E2F transcription factors and other regulatory proteins. We present the first structures of phosphorylated Rb that reveal the mechanism of its inactivati...

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Detalles Bibliográficos
Autores principales: Burke, Jason R., Hura, Greg L., Rubin, Seth M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371405/
https://ncbi.nlm.nih.gov/pubmed/22569856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.189837.112
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