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Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control
Cyclin-dependent kinase (Cdk) phosphorylation of the Retinoblastoma protein (Rb) drives cell proliferation through inhibition of Rb complexes with E2F transcription factors and other regulatory proteins. We present the first structures of phosphorylated Rb that reveal the mechanism of its inactivati...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3371405/ https://ncbi.nlm.nih.gov/pubmed/22569856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.189837.112 |
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