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Multiple Mechanisms for E2F Binding Inhibitionby Phosphorylation of the Retinoblastoma Protein C-terminal Domain
The retinoblastoma proteinC-terminal domain (RbC) is necessary for the tumor suppressor protein's activities in growth suppression and E2F transcription factor inhibition. Cyclin-dependent kinase phosphorylation of RbC contributes to Rb inactivation and weakens the Rb-E2F inhibitory complex. He...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3872205/ https://ncbi.nlm.nih.gov/pubmed/24103329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.09.031 |
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