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Pseudouridylation of 7SK snRNA promotes 7SK snRNP formation to suppress HIV‐1 transcription and escape from latency
The 7SK snRNA sequesters P‐TEFb, a general transcription elongation factor and human co‐factor for HIV‐1 Tat protein, into the catalytically inactive 7SK snRNP. Little is known about how 7SK RNA is regulated to perform this function. Here, we show that most of 7SK is pseudouridylated at position U25...
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| Published in: | EMBO Rep |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley and Sons Inc.
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5048380/ https://ncbi.nlm.nih.gov/pubmed/27558685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642682 |
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