A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

Although β-blockers can be used to eliminate stress-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), this treatment is unsuccessful in ∼25% of cases. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) generated from these pat...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Preininger, Marcela K., Jha, Rajneesh, Maxwell, Joshua T., Wu, Qingling, Singh, Monalisa, Wang, Bo, Dalal, Aarti, Mceachin, Zachary T., Rossoll, Wilfried, Hales, Chadwick M., Fischbach, Peter S., Wagner, Mary B., Xu, Chunhui
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047684/
https://ncbi.nlm.nih.gov/pubmed/27491078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.026823
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