RGS14 regulates the lifetime of Gα‐GTP signaling but does not prolong Gβγ signaling following receptor activation in live cells

RGS14 is a multifunctional scaffolding protein possessing two distinct G protein interaction sites including a regulator of G protein signaling (RGS) domain that acts as a GTPase activating protein (GAP) to deactivate Gαi/o‐GTP proteins, and a G protein regulatory (GPR) motif that binds inactive Gαi...

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Bibliographic Details
Published in:Pharmacol Res Perspect
Main Authors: Brown, Nicole E., Lambert, Nevin A., Hepler, John R.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045935/
https://ncbi.nlm.nih.gov/pubmed/27713821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.249
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