Substantial inter-individual and limited intra-individual genomic diversity among tumors from men with metastatic prostate cancer

Intra-individual tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases wit...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Kumar, Akash, Coleman, Ilsa, Morrissey, Colm, Zhang, Xiaotun, True, Lawrence D., Gulati, Roman, Etzioni, Ruth, Bolouri, Hamid, Montgomery, Bruce, White, Thomas, Lucas, Jared M., Brown, Lisha G., Dumpit, Ruth F., DeSarkar, Navonil, Higano, Celestia, Yu, Evan Y., Coleman, Roger, Schultz, Nikolaus, Fang, Min, Lange, Paul H., Shendure, Jay, Vessella, Robert L., Nelson, Peter S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045679/
https://ncbi.nlm.nih.gov/pubmed/26928463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4053
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