Substantial inter-individual and limited intra-individual genomic diversity among tumors from men with metastatic prostate cancer

Intra-individual tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases wit...

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Publicat a:Nat Med
Autors principals: Kumar, Akash, Coleman, Ilsa, Morrissey, Colm, Zhang, Xiaotun, True, Lawrence D., Gulati, Roman, Etzioni, Ruth, Bolouri, Hamid, Montgomery, Bruce, White, Thomas, Lucas, Jared M., Brown, Lisha G., Dumpit, Ruth F., DeSarkar, Navonil, Higano, Celestia, Yu, Evan Y., Coleman, Roger, Schultz, Nikolaus, Fang, Min, Lange, Paul H., Shendure, Jay, Vessella, Robert L., Nelson, Peter S.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045679/
https://ncbi.nlm.nih.gov/pubmed/26928463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4053
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