Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging

The aim of this study was to clarify the synergistic effects of dual inhibition of the PI3K/mTOR and MAPK pathways in ovarian mucinous carcinoma (OMC) cells, using fluorescence resonance energy transfer (FRET) imaging. We exposed 6 OMC cell lines to a PI3K/mTOR inhibitor (voxtalisib, SAR245409) and/...

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發表在:Oncotarget
Main Authors: Inaba, Kanako, Oda, Katsutoshi, Aoki, Kazuhiro, Sone, Kenbun, Ikeda, Yuji, Miyasaka, Aki, Kashiyama, Tomoko, Fukuda, Tomohiko, Makii, Chinami, Arimoto, Takahide, Wada-Hiraike, Osamu, Kawana, Kei, Yano, Tetsu, Osuga, Yutaka, Fujii, Tomoyuki
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045418/
https://ncbi.nlm.nih.gov/pubmed/27102436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8807
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