Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging

The aim of this study was to clarify the synergistic effects of dual inhibition of the PI3K/mTOR and MAPK pathways in ovarian mucinous carcinoma (OMC) cells, using fluorescence resonance energy transfer (FRET) imaging. We exposed 6 OMC cell lines to a PI3K/mTOR inhibitor (voxtalisib, SAR245409) and/...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Inaba, Kanako, Oda, Katsutoshi, Aoki, Kazuhiro, Sone, Kenbun, Ikeda, Yuji, Miyasaka, Aki, Kashiyama, Tomoko, Fukuda, Tomohiko, Makii, Chinami, Arimoto, Takahide, Wada-Hiraike, Osamu, Kawana, Kei, Yano, Tetsu, Osuga, Yutaka, Fujii, Tomoyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045418/
https://ncbi.nlm.nih.gov/pubmed/27102436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8807
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