Antitumor Activity and Induction of TP53-Dependent Apoptosis toward Ovarian Clear Cell Adenocarcinoma by the Dual PI3K/mTOR Inhibitor DS-7423

DS-7423, a novel, small-molecule dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR), is currently in phase I clinical trials for solid tumors. Although DS-7423 potently inhibits PI3Kα (IC(50) = 15.6 nM) and mTOR (IC(50) = 34.9 nM), it also inhibits other...

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Main Authors: Kashiyama, Tomoko, Oda, Katsutoshi, Ikeda, Yuji, Shiose, Yoshinobu, Hirota, Yasuhide, Inaba, Kanako, Makii, Chinami, Kurikawa, Reiko, Miyasaka, Aki, Koso, Takahiro, Fukuda, Tomohiko, Tanikawa, Michihiro, Shoji, Keiko, Sone, Kenbun, Arimoto, Takahide, Wada-Hiraike, Osamu, Kawana, Kei, Nakagawa, Shunsuke, Matsuda, Koichi, McCormick, Frank, Aburatani, Hiroyuki, Yano, Tetsu, Osuga, Yutaka, Fujii, Tomoyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913610/
https://ncbi.nlm.nih.gov/pubmed/24504419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087220
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