Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells

BACKGROUND: PTEN inactivation is the most frequent genetic aberration in endometrial cancer. One of the phosphatase-independent roles of PTEN is associated with homologous recombination (HR) in nucleus. Poly (ADP-ribose) polymerase (PARP) plays key roles in the repair of DNA single-strand breaks, an...

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Bibliografiske detaljer
Main Authors: Miyasaka, Aki, Oda, Katsutoshi, Ikeda, Yuji, Wada-Hiraike, Osamu, Kashiyama, Tomoko, Enomoto, Atsushi, Hosoya, Noriko, Koso, Takahiro, Fukuda, Tomohiko, Inaba, Kanako, Sone, Kenbun, Uehara, Yuriko, Kurikawa, Reiko, Nagasaka, Kazunori, Matsumoto, Yoko, Arimoto, Takahide, Nakagawa, Shunsuke, Kuramoto, Hiroyuki, Miyagawa, Kiyoshi, Yano, Tetsu, Kawana, Kei, Osuga, Yutaka, Fujii, Tomoyuki
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007824/
https://ncbi.nlm.nih.gov/pubmed/24625059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-179
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