Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of clonal plasma cells in the bone marrow leading to bone destruction and bone marrow failure. Several molecular mechanisms underlie chemoresistance among which heme oxygenase-1 (HO-1) could play a major role. The a...

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Pubblicato in:Oncotarget
Autori principali: Tibullo, Daniele, Barbagallo, Ignazio, Giallongo, Cesarina, Vanella, Luca, Conticello, Concetta, Romano, Alessandra, Saccone, Salvatore, Godos, Justyna, Di Raimondo, Francesco, Li Volti, Giovanni
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045362/
https://ncbi.nlm.nih.gov/pubmed/26930712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7563
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