Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells

Osteolytic bone disease is a common manifestation of multiple myeloma (MM) that leads to progressive skeleton destruction and is the most severe cause of morbidity in MM patients. It results from increased osteolytic activity and decrease osteoblastic function. Activation of mammalian chitinases chi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Tibullo, Daniele, Di Rosa, Michelino, Giallongo, Cesarina, La Cava, Piera, Parrinello, Nunziatina L., Romano, Alessandra, Conticello, Concetta, Brundo, Maria V., Saccone, Salvatore, Malaguarnera, Lucia, Di Raimondo, Francesco
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2015
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604315/
https://ncbi.nlm.nih.gov/pubmed/26528182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00226
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