Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of clonal plasma cells in the bone marrow leading to bone destruction and bone marrow failure. Several molecular mechanisms underlie chemoresistance among which heme oxygenase-1 (HO-1) could play a major role. The a...

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Vydáno v:Oncotarget
Hlavní autoři: Tibullo, Daniele, Barbagallo, Ignazio, Giallongo, Cesarina, Vanella, Luca, Conticello, Concetta, Romano, Alessandra, Saccone, Salvatore, Godos, Justyna, Di Raimondo, Francesco, Li Volti, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045362/
https://ncbi.nlm.nih.gov/pubmed/26930712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7563
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