Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of clonal plasma cells in the bone marrow leading to bone destruction and bone marrow failure. Several molecular mechanisms underlie chemoresistance among which heme oxygenase-1 (HO-1) could play a major role. The a...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Tibullo, Daniele, Barbagallo, Ignazio, Giallongo, Cesarina, Vanella, Luca, Conticello, Concetta, Romano, Alessandra, Saccone, Salvatore, Godos, Justyna, Di Raimondo, Francesco, Li Volti, Giovanni
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045362/
https://ncbi.nlm.nih.gov/pubmed/26930712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7563
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