Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Reversible infantile liver failure (RILF) is a unique heritable liver disease characterized by acute liver failure followed by spontaneous recovery at an early stage of life. Genetic mutations in MTU1 have been identified in RILF patients. MTU1 is a mitochondrial enzyme that catalyzes the 2-thiolati...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:PLoS Genet
Autores principales: Wu, Yong, Wei, Fan-Yan, Kawarada, Layla, Suzuki, Takeo, Araki, Kimi, Komohara, Yoshihiro, Fujimura, Atsushi, Kaitsuka, Taku, Takeya, Motohiro, Oike, Yuichi, Suzuki, Tsutomu, Tomizawa, Kazuhito
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045200/
https://ncbi.nlm.nih.gov/pubmed/27689697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006355
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares