Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Reversible infantile liver failure (RILF) is a unique heritable liver disease characterized by acute liver failure followed by spontaneous recovery at an early stage of life. Genetic mutations in MTU1 have been identified in RILF patients. MTU1 is a mitochondrial enzyme that catalyzes the 2-thiolati...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Genet
Egile Nagusiak: Wu, Yong, Wei, Fan-Yan, Kawarada, Layla, Suzuki, Takeo, Araki, Kimi, Komohara, Yoshihiro, Fujimura, Atsushi, Kaitsuka, Taku, Takeya, Motohiro, Oike, Yuichi, Suzuki, Tsutomu, Tomizawa, Kazuhito
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045200/
https://ncbi.nlm.nih.gov/pubmed/27689697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006355
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