Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Reversible infantile liver failure (RILF) is a unique heritable liver disease characterized by acute liver failure followed by spontaneous recovery at an early stage of life. Genetic mutations in MTU1 have been identified in RILF patients. MTU1 is a mitochondrial enzyme that catalyzes the 2-thiolati...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Wu, Yong, Wei, Fan-Yan, Kawarada, Layla, Suzuki, Takeo, Araki, Kimi, Komohara, Yoshihiro, Fujimura, Atsushi, Kaitsuka, Taku, Takeya, Motohiro, Oike, Yuichi, Suzuki, Tsutomu, Tomizawa, Kazuhito
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045200/
https://ncbi.nlm.nih.gov/pubmed/27689697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006355
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