A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

The inward Na+ current underlying the action potential in nerve is terminated by inactivation. The preceding report shows that deletions within the intracellular linker between domains III and IV remove inactivation, but mutation of conserved basic and paired acidic amino acids has little effect. He...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	West, J W, Patton, D E, Scheuer, T, Wang, Y, Goldin, A L, Catterall, W A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50452/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1332060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.22.10910
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