The role of PHD2 mutations in the pathogenesis of erythrocytosis

The transcription of the erythropoietin (EPO) gene is tightly regulated by the hypoxia response pathway to maintain oxygen homeostasis. Elevations in serum EPO level may be reflected in an augmentation in the red cell mass, thereby causing erythrocytosis. Studies on erythrocytosis have provided insi...

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Detalles Bibliográficos
Publicado en:Hypoxia (Auckl)
Main Authors: Gardie, Betty, Percy, Melanie J, Hoogewijs, David, Chowdhury, Rasheduzzaman, Bento, Celeste, Arsenault, Patrick R, Richard, Stéphane, Almeida, Helena, Ewing, Joanne, Lambert, Frédéric, McMullin, Mary Frances, Schofield, Christopher J, Lee, Frank S
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2014
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045058/
https://ncbi.nlm.nih.gov/pubmed/27774468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/HP.S54455
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