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Epitope-Independent Purification of Native-Like Envelope Trimers from Diverse HIV-1 Isolates

Soluble forms of trimeric HIV-1 envelope glycoprotein (Env) have long been sought as immunogens and as reagents for analysis of Env structure and function. Isolation of trimers that mimic native Env, derived from diverse viruses, however, represents a major challenge. Thus far, the most promising na...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Verkerke, Hans P., Williams, James A., Guttman, Miklos, Simonich, Cassandra A., Liang, Yu, Filipavicius, Modestas, Hu, Shiu-Lok, Overbaugh, Julie, Lee, Kelly K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5044855/
https://ncbi.nlm.nih.gov/pubmed/27512064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01351-16
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