Comparative Immunogenicity of Subtype A Human Immunodeficiency Virus Type 1 Envelope Exhibiting Differential Exposure of Conserved Neutralization Epitopes

Development of broadly cross-reactive neutralizing antibodies (NAbs) remains a major goal of HIV-1 vaccine development, but most candidate envelope immunogens have had limited ability to cross-neutralize heterologous strains. To evaluate the immunogenicity of subtype A variants of HIV-1, rabbits wer...

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Main Authors: Blish, Catherine A., Sather, D. Noah, Sellhorn, George, Stamatatos, Leonidas, Sun, Yide, Srivastava, Indresh, Barnett, Susan W., Cleveland, Brad, Overbaugh, Julie, Hu, Shiu-lok
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820908/
https://ncbi.nlm.nih.gov/pubmed/20015987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01687-09
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