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Changes in the Immunogenic Properties of Soluble gp140 Human Immunodeficiency Virus Envelope Constructs upon Partial Deletion of the Second Hypervariable Region

Immunization of macaques with the soluble oligomeric gp140 form of the SF162 envelope (SF162gp140) or with an SF162gp140-derived construct lacking the central region of the V2 loop (ΔV2gp140) results in the generation of high titers of antibodies capable of neutralizing the homologous human immunode...

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Autors principals: Srivastava, Indresh K., VanDorsten, Keating, Vojtech, Lucia, Barnett, Susan W., Stamatatos, Leonidas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC141106/
https://ncbi.nlm.nih.gov/pubmed/12551968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.4.2310-2320.2003
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