Changes in the Immunogenic Properties of Soluble gp140 Human Immunodeficiency Virus Envelope Constructs upon Partial Deletion of the Second Hypervariable Region

Immunization of macaques with the soluble oligomeric gp140 form of the SF162 envelope (SF162gp140) or with an SF162gp140-derived construct lacking the central region of the V2 loop (ΔV2gp140) results in the generation of high titers of antibodies capable of neutralizing the homologous human immunode...

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Hlavní autoři: Srivastava, Indresh K., VanDorsten, Keating, Vojtech, Lucia, Barnett, Susan W., Stamatatos, Leonidas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC141106/
https://ncbi.nlm.nih.gov/pubmed/12551968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.4.2310-2320.2003
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