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Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

The deposition of amyloid in senile plaques and along the walls of the cerebral vasculature is a characteristic feature of Alzheimer disease. The peptide comprising the carboxyl-terminal 100 amino acids of the beta-amyloid precursor protein (beta APP) has been shown to aggregate into amyloid-like fi...

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Détails bibliographiques
Auteurs principaux: Kammesheidt, A, Boyce, F M, Spanoyannis, A F, Cummings, B J, Ortegón, M, Cotman, C, Vaught, J L, Neve, R L
Format: Artigo
Langue:Inglês
Publié: 1992
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC50441/
https://ncbi.nlm.nih.gov/pubmed/1438289
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