Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer’s disease

BACKGROUND: Presenilin-1 (PS1), the active component of the intramembrane γ-secretase complex, can be detected as soluble heteromeric aggregates in cerebrospinal fluid (CSF). The aim of this study was to examine the different soluble PS1 complexes in the lumbar CSF (CSF-PS1) of individuals with Alzh...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Neurodegener
Päätekijät: Sogorb-Esteve, Aitana, García-Ayllón, María-Salud, Fortea, Juan, Sánchez-Valle, Raquel, Lleó, Alberto, Molinuevo, José-Luis, Sáez-Valero, Javier
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043603/
https://ncbi.nlm.nih.gov/pubmed/27686161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0131-2
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