Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer’s disease

BACKGROUND: Presenilin-1 (PS1), the active component of the intramembrane γ-secretase complex, can be detected as soluble heteromeric aggregates in cerebrospinal fluid (CSF). The aim of this study was to examine the different soluble PS1 complexes in the lumbar CSF (CSF-PS1) of individuals with Alzh...

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Bibliografische gegevens
Gepubliceerd in:Mol Neurodegener
Hoofdauteurs: Sogorb-Esteve, Aitana, García-Ayllón, María-Salud, Fortea, Juan, Sánchez-Valle, Raquel, Lleó, Alberto, Molinuevo, José-Luis, Sáez-Valero, Javier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2016
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043603/
https://ncbi.nlm.nih.gov/pubmed/27686161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0131-2
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