Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer’s disease

BACKGROUND: Presenilin-1 (PS1), the active component of the intramembrane γ-secretase complex, can be detected as soluble heteromeric aggregates in cerebrospinal fluid (CSF). The aim of this study was to examine the different soluble PS1 complexes in the lumbar CSF (CSF-PS1) of individuals with Alzh...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Sogorb-Esteve, Aitana, García-Ayllón, María-Salud, Fortea, Juan, Sánchez-Valle, Raquel, Lleó, Alberto, Molinuevo, José-Luis, Sáez-Valero, Javier
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043603/
https://ncbi.nlm.nih.gov/pubmed/27686161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0131-2
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