Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.

Torpedo acetylcholinesterase (AcChoEase, EC 3.1.1.7) and human butyrylcholinesterase (BtChoEase, EC 3.1.1.8), while clearly differing in substrate specificity and sensitivity to inhibitors, possess 53% sequence homology; this permitted modeling human BtChoEase on the basis of the three-dimensional s...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Harel, M, Sussman, J L, Krejci, E, Bon, S, Chanal, P, Massoulié, J, Silman, I
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50435/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438284/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.22.10827
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