Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.

Torpedo acetylcholinesterase (AcChoEase, EC 3.1.1.7) and human butyrylcholinesterase (BtChoEase, EC 3.1.1.8), while clearly differing in substrate specificity and sensitivity to inhibitors, possess 53% sequence homology; this permitted modeling human BtChoEase on the basis of the three-dimensional s...

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Bibliographic Details
Main Authors: Harel, M, Sussman, J L, Krejci, E, Bon, S, Chanal, P, Massoulié, J, Silman, I
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC50435/
https://ncbi.nlm.nih.gov/pubmed/1438284
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