An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase.
Electrostatic calculations based on the recently solved crystal structure of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) indicate that this enzyme has a strong electrostatic dipole. The dipole is aligned with the gorge leading to its active site, so that a positively charged sub...
Na minha lista:
| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46668/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8506359/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.5128 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|