HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances

Despite remarkable successes with targeted therapies in the treatment of cancer, resistance can occur which limits the clinical outcome. In this study, we generated and characterized resistant cell clones derived from two different head and neck squamous cell carcinoma (HNSCC) cell lines (Cal27, UD-...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Schulz, Dominik, Wirth, Markus, Piontek, Guido, Buchberger, Anna Maria Stefanie, Schlegel, Jürgen, Reiter, Rudolf, Multhoff, Gabriele, Pickhard, Anja
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043106/
https://ncbi.nlm.nih.gov/pubmed/27725902
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