HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances

Despite remarkable successes with targeted therapies in the treatment of cancer, resistance can occur which limits the clinical outcome. In this study, we generated and characterized resistant cell clones derived from two different head and neck squamous cell carcinoma (HNSCC) cell lines (Cal27, UD-...

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Bibliografiske detaljer
Udgivet i:Am J Cancer Res
Main Authors: Schulz, Dominik, Wirth, Markus, Piontek, Guido, Buchberger, Anna Maria Stefanie, Schlegel, Jürgen, Reiter, Rudolf, Multhoff, Gabriele, Pickhard, Anja
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043106/
https://ncbi.nlm.nih.gov/pubmed/27725902
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