Targeting Protein Homeostasis in Sporadic Inclusion Body Myositis

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients over age 50. Previous therapeutic trials have targeted the inflammatory features of sIBM, but all have failed. Since protein dyshomeostasis may also play a role in sIBM, we tested the effects of targeting this featu...

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Publicado en:Sci Transl Med
Main Authors: Ahmed, Mhoriam, Machado, Pedro M., Miller, Adrian, Spicer, Charlotte, Herbelin, Laura, He, Jianghua, Noel, Janelle, Wang, Yunxia, McVey, April L., Pasnoor, Mamatha, Gallagher, Philip, Statland, Jeffrey, Lu, Ching-Hua, Kalmar, Bernadett, Brady, Stefen, Sethi, Huma, Samandouras, George, Parton, Matt, Holton, Janice L., Weston, Anne, Collinson, Lucy, Taylor, J. Paul, Schiavo, Giampietro, Hanna, Michael G., Barohn, Richard J., Dimachkie, Mazen M., Greensmith, Linda
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043094/
https://ncbi.nlm.nih.gov/pubmed/27009270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad4583
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