Targeting Protein Homeostasis in Sporadic Inclusion Body Myositis

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients over age 50. Previous therapeutic trials have targeted the inflammatory features of sIBM, but all have failed. Since protein dyshomeostasis may also play a role in sIBM, we tested the effects of targeting this featu...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Sci Transl Med
Κύριοι συγγραφείς: Ahmed, Mhoriam, Machado, Pedro M., Miller, Adrian, Spicer, Charlotte, Herbelin, Laura, He, Jianghua, Noel, Janelle, Wang, Yunxia, McVey, April L., Pasnoor, Mamatha, Gallagher, Philip, Statland, Jeffrey, Lu, Ching-Hua, Kalmar, Bernadett, Brady, Stefen, Sethi, Huma, Samandouras, George, Parton, Matt, Holton, Janice L., Weston, Anne, Collinson, Lucy, Taylor, J. Paul, Schiavo, Giampietro, Hanna, Michael G., Barohn, Richard J., Dimachkie, Mazen M., Greensmith, Linda
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2016
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043094/
https://ncbi.nlm.nih.gov/pubmed/27009270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad4583
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