Targeting Protein Homeostasis in Sporadic Inclusion Body Myositis

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients over age 50. Previous therapeutic trials have targeted the inflammatory features of sIBM, but all have failed. Since protein dyshomeostasis may also play a role in sIBM, we tested the effects of targeting this featu...

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Bibliografiska uppgifter
I publikationen:Sci Transl Med
Huvudupphovsmän: Ahmed, Mhoriam, Machado, Pedro M., Miller, Adrian, Spicer, Charlotte, Herbelin, Laura, He, Jianghua, Noel, Janelle, Wang, Yunxia, McVey, April L., Pasnoor, Mamatha, Gallagher, Philip, Statland, Jeffrey, Lu, Ching-Hua, Kalmar, Bernadett, Brady, Stefen, Sethi, Huma, Samandouras, George, Parton, Matt, Holton, Janice L., Weston, Anne, Collinson, Lucy, Taylor, J. Paul, Schiavo, Giampietro, Hanna, Michael G., Barohn, Richard J., Dimachkie, Mazen M., Greensmith, Linda
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043094/
https://ncbi.nlm.nih.gov/pubmed/27009270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad4583
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