Targeting Protein Homeostasis in Sporadic Inclusion Body Myositis

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients over age 50. Previous therapeutic trials have targeted the inflammatory features of sIBM, but all have failed. Since protein dyshomeostasis may also play a role in sIBM, we tested the effects of targeting this featu...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Ahmed, Mhoriam, Machado, Pedro M., Miller, Adrian, Spicer, Charlotte, Herbelin, Laura, He, Jianghua, Noel, Janelle, Wang, Yunxia, McVey, April L., Pasnoor, Mamatha, Gallagher, Philip, Statland, Jeffrey, Lu, Ching-Hua, Kalmar, Bernadett, Brady, Stefen, Sethi, Huma, Samandouras, George, Parton, Matt, Holton, Janice L., Weston, Anne, Collinson, Lucy, Taylor, J. Paul, Schiavo, Giampietro, Hanna, Michael G., Barohn, Richard J., Dimachkie, Mazen M., Greensmith, Linda
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043094/
https://ncbi.nlm.nih.gov/pubmed/27009270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad4583
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