Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

It is well known that isolation and cultivation of primary hepatocytes cause major gene expression alterations. In the present genome-wide, time-resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in liver...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arch Toxicol
Prif Awduron: Godoy, Patricio, Widera, Agata, Schmidt-Heck, Wolfgang, Campos, Gisela, Meyer, Christoph, Cadenas, Cristina, Reif, Raymond, Stöber, Regina, Hammad, Seddik, Pütter, Larissa, Gianmoena, Kathrin, Marchan, Rosemarie, Ghallab, Ahmed, Edlund, Karolina, Nüssler, Andreas, Thasler, Wolfgang E., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Dirsch, Olaf, Dahmen, Uta, Gebhardt, Rolf, Chaudhari, Umesh, Meganathan, Kesavan, Sachinidis, Agapios, Kelm, Jens, Hofmann, Ute, Zahedi, René P., Guthke, Reinhard, Blüthgen, Nils, Dooley, Steven, Hengstler, Jan G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2016
Pynciau:
In vitro Systems
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043005/
https://ncbi.nlm.nih.gov/pubmed/27339419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1761-4
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