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Chemical approach to positional isomers of glucose-platinum conjugates reveals specific cancer targeting through glucose-transporter mediated uptake in vitro and in vivo

Glycoconjugation is a promising strategy for specific targeting of cancer. In this study, we investigated the effect of D-glucose substitution position on the biological activity of glucose-platinum conjugates (Glc-Pts). We synthesized and characterized all possible positional isomers (C1α, C1β, C2,...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Patra, Malay, Awuah, Samuel G., Lippard, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042873/
https://ncbi.nlm.nih.gov/pubmed/27570149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b06937
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