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A potent glucose-platinum conjugate exploits glucose transporters and preferentially accumulates in cancer cells
Three rationally designed glucose-platinum conjugates (Glc-Pts) were synthesized and their biological activities evaluated. The Glc-Pts, 1-3, exhibit high levels of cytotoxicity toward a panel of cancer cells. The subcellular target and cellular uptake mechanism of the Glc-Pts were elucidated. For u...
Tallennettuna:
| Julkaisussa: | Angew Chem Int Ed Engl |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4752825/ https://ncbi.nlm.nih.gov/pubmed/26749149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201510551 |
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